[Faithful Reader]

As we are in our global self-isolation, let's look back at the episodes that took advantage of their standing sets to show an almost empty ship.

The Mark of Gideon - The end of the episode spoils it, but most of this episode is Kirk wandering around the set.

Remember Me - A good mystery episode ending up with Dr. Crusher on her own.

Starship Mine - Die Hard in space, but Picard held his own against a rag tag band of mercenaries.

Distant Voices - Bashir wandered around the abandoned station that was his mind.

Displaced - This is a bit of a cheat, but Chakotay did have a fun scene with an ensign on her first day of bridge duty.

Those are off teh top of my head. Any others?

[Data's Socks]

"Macrocosm" especially with that small problem afflicting their ship.

[eberlems]

Not all ship based, but quarantine or isolated:

The Next Generation: Unnatural Selection
Voyager: One
Voyager: Resolutions
Enterprise: Doctor's Orders

[Ensign Q]

Tng genesis

[RogersAmanda]

I may be a little off the discussion but I think you'll pardon me for being right on topic with the title of this Post...

Babel (DS9 S1:E5)
Star Trek: Deep Space Nine" Babel (TV Episode 1993) - IMDb

Life imitating Art imitating Life (repeat about every 100 years on Earth, or wait 18 years on DS9)