[rferries]

Here's a version more worthy of a series finale, a la Destroy Transwarp Hub. You can have contemporary Picard plus his past and future selves (and more!).

•Collapse Anti-Time Anomaly, Cross-Temporal Cooperation
50
Astrometrics, Diplomacy, Leadership, Science, 3 Physics, Cunning>44, and a Q event
Region: Neutral Zone. You may play and command multiple unique cards with the same title with different , and icons (only one of those cards may lack all three of , , and ).
Devron system: "The only way to stop this thing is to repair the rupture at the focal point where time and anti-time are converging."
Any affiliation may attempt this mission.
Span 3

[rferries]

•Ba'ku Planet, Fountain of Youth
50
2 Astrometrics, 2 Leadership, Physics, Security, Strength>44, and (Anthropology and Honour or Transporters and Treachery)
Region: Briar Patch.When your personnel complete this mission using Honour, you may download up to three personnel and place them here. If your personnel completed this mission using Treachery, your personnel cannot be killed by dilemmas.
" Who wouldn't be tempted by the promise of perpetual youth?"
Any affiliation may attempt this mission.
Span 2

Reunite the Ba'ku and the Son'a (bah humbug), or put the healing radiation to actual good use for the rest of the galaxy.

[rferries]

•Veridian III, Nexus Encounter
50
3 Astrometrics, Leadership, 2 Physics, Science, and (Honour and Integrity>48 or Treachery and Cunning>48)
When your personnel complete this mission using Honour, you may place any number of personnel you own that have been removed from the game here. When your personnel complete this mission using Treachery, each player scores 5 points for each personnel they own that has been removed from the game (limit 20).
"Time has no meaning there. The predator has no teeth."
Any affiliation may attempt this mission.
Span 2

Temporal Energy Flux Ribbon synergy. Bring Kirk and Picard back out of the Nexus, or help Soran escape into it.

[rferries]

•Battle of Cardassia, Finish the Dominion War
50
Officer, 3 Leadership, 2 Security, Strength>44, and total Weapons at this mission>14
Region: Cardassia System. Each ship at this mission requires one less damage card to destroy it. Maneuver events may be played at cost-1.
Near Cardassia Prime: "The outcome of this battle will determine the outcome of the war."

Span 2

[rferries]

•Fire Caves, Control Celestial Temple
50
3 Anthropology, 2 Leadership, and (3 Honour and Integrity>48 or 3 Treachery and Cunning>48)
Region: Bajor System. To complete this mission you must command Bajor and Mouth of the Wormhole. Artifact, Pah Wraith, Prophet, and Temporal cards are cost-1. If this mission is completed and you have 100 or more points, you win the game.
"The Prophets have sent me a gift. Their beloved Emissary, set forth like an avenging angel to slay the demon."

Span 2

[rferries]

•Galactic Barrier, Where No Man Has Gone Before
50
2 Astrometrics, 2 Navigation, Physics, Science, Cunning>44, and a ship with Range>7
Region: Galactic Barrier. When you begin or fail a mission attempt at this mission, kill a random personnel present. While this mission is complete your unique personnel are attributes+3 and gain Telepathy.
"Our overriding question now is – what destroyed the Valiant? They lived through the barrier, just as we have. What happened to them after that?"
Any affiliation may attempt this mission.
Span 4

Arguably the premiere of TOS.

•Mars, Terra Prime's Last Stand
50
Engineering, Intelligence, Leadership, 2 Security, Strength>44, and (2 Treachery and no non-Human personnel or Honour and two non-Human personnel)
Region: Sector 001. When you complete this mission using Treachery, each player kills a random non-Human personnel they command. If this mission was completed using Honour, your personnel are attributes+1 while present with a personnel of a different species.
"I have no intention of using this weapon again, provided that every single non-human on this planet leaves immediately."

Span 2

A fitting end to the Enterprise series. There were no subsequent episodes, no sir.